Featured Publications

Raju S*, Adams LJ*, Earnest JT, Warfield K, Vang L, Crowe JE Jr, Fremont DH, Diamond MS. A chikungunya virus-like particle vaccine induces broadly neutralizing and protective antibodies against alphaviruses in humans. Sci Transl Med. 2023 May 17;15(696):eade8273. PMID: 37196061

Raju S*, Palakurty S*, Sariol A, Wagoner N, Adams LJ, Hui S, Klimstra WB, Fremont DH, Diamond MS. Structural basis for plasticity in receptor engagement by an encephalitic alphavirus. Cell; 2025 Apr 4;188(11):2943-2956.e24. PMID: 40187344

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Peer-Reviewed Publications (Reverse Chronologic)

  1. Raju S*, Palakurty S*, Sariol A, Wagoner N, Adams LJ, Hui S, Klimstra WB, Fremont DH, Diamond MS. Structural basis for plasticity in receptor engagement by an encephalitic alphavirus. Cell. 2025 Apr 4:S0092-8674(25)00272-7. PMID: 40187344 *co-first authors
  1. Palakurty S*, Raju S*, Sariol A*, Chong Z, Wagoner N, Ma H, Zimmerman O, Adams LJ, Carmona C, Liu Z, Fremont DH, Whelan SPJ, Klimstra WB, Diamond MS. The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses. Cell Reports; 2024 Oct 5;43(10):114809. PMID: 39369384 *co-first authors
  1. Liang CY, Raju S, Liu Z, Li Y, Asthagiri Arunkumar G, Case JB, Scheaffer SM, Zost SJ, Acreman CM, Gagne M, Andrew SF, Carvalho Dos Anjos DC, Foulds KE, McLellan JS, Crowe JE Jr, Douek DC, Whelan SPJ, Elbashir SM, Edwards DK, Diamond MS. Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines. Nature. 2024 May 15; PMID: 38749479
  1. Ying B, Darling TL, Desai P, Liang CY, Dmitriev IP, Soudani N, Bricker T, Kashentseva EA, Harastani H, Raju S, Liu M, Schmidt AG, Curiel DT, Boon ACM, Diamond MS. Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection. Nature Immunology. 2024 Feb 9;1–15. PMID: 38337035
  1. Zimmerman O, Doss AMA, Ying B, Liang CY, Mackin SR, Davis-Adams HG, Adams LJ, VanBlargan LA, Chen RE, Scheaffer SM, Desai P, Raju S, Mantia TL, O’Shaughnessy CC, Monroy JM, Wedner HJ, Rigell CJ, Kau AL, Dy TB, Ren Z, Turner JS, O’Halloran JA, Presti RM, Kendall PL, Fremont DH, Ellebedy AH, Diamond MS. Immunoglobulin replacement products protect against SARS-CoV-2 infection in vivo despite poor neutralizing activity. JCI Insight. 2024 Feb 8;9(3):e176359.. PMID: 38175703
  1. Ma H, Adams LJ, Raju S, Sariol A, Kafai NM, Janova H, Klimstra WB, Fremont DH, Diamond MS. The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses. Nature Communications. 2024 Jan 4;15(1):246. PMCID: PMC10764363
  1. Adams LJ*, Raju S*, Ma H, Gilliland T Jr, Reed DS, Klimstra WB, Fremont DH, Diamond MS. Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus. Cell. 2024 Jan 18;187(2):360–374.e19. PMCID: PMC10843625. *co-first authors
  1. Adams LJ, VanBlargan LA, Liu Z, Gilchuk P, Zhao H, Chen RE, Raju S, Chong Z, Whitener BM, Shrihari S, Jethva PN, Gross ML, Crowe JE Jr, Whelan SPJ, Diamond MS, Fremont DH. A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection. Cell Reports Medicine 2023 Dec 19;4(12):101305. PMCID: PMC10772349
  1. Zimmerman, O.*, Zimmerman, M. I.*, Raju, S.*, Nelson, C. A., Errico, J. M., Madden, E. A., Holmes, A. C., Hassan, A. O., VanBlargan, L. A., Kim, A. S., Adams, L. J., Basore, K., Whitener, B. M., Palakurty, S., Davis-Adams, H. G., Sun, C., Earnest, J. T., Ma, H., Ebel, G. D., Zmasek, C., Scheuermann, R. H., Klimstra, W. B., Fremont, D. H., & Diamond, M. S. (2023). Host species-specific binding modes of MXRA8 receptor by alphaviruses enables generation of a broad-spectrum decoy inhibitor. Cell. 2023 Oct 6:S0092-8674(23)01029-2. PMID: 37804831. *co-first authors
  1. Raju S*, Adams LJ*, Earnest JT, Warfield K, Vang L, Crowe JE Jr, Fremont DH, Diamond MS. A chikungunya virus-like particle vaccine induces broadly neutralizing and protective antibodies against alphaviruses in humans. Sci Transl Med. 2023 May 17;15(696):eade8273. PMID: 37196061 *co-first authors
  1. Lin FJ, Doss AMA, Davis-Adams HG, Adams LJ, Hanson CH, VanBlargan LA, Liang CY, Chen RE, Monroy JM, Wedner HJ, Kulczycki A, Mantia TL, O’Shaughnessy CC, Raju S, Zhao FR, Rizzi E, Rigell CJ, Dy TB, Kau AL, Ren Z, Turner JS, O’Halloran JA, Presti RM, Fremont DH, Kendall PL, Ellebedy AH, Mudd PA, Diamond MS, Zimmerman O, Laidlaw BJ. SARS-CoV-2 booster vaccination rescues attenuated IgG1 memory B cell response in primary antibody deficiency patients. Front Immunol. 2022 Dec 22;13:1033770. PMCID: PMC9817149
  1. Xia Y, Sandor K, Pai JA, Daniel B, Raju S, Wu R, Hsiung S, Qi Y, Yangdon T, Okamoto M, Chou C, Hiam-Galvez KJ, Schreiber RD, Murphy KM, Satpathy AT, Egawa T. BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4+ T cell responses to persistent antigen. Immunity. 2022 Jul 12;55(7):1200-1215.e6. PMCID: PMC10034764
  1. Zimmerman O, Altman Doss AM, Kaplonek P, Liang CY, VanBlargan LA, Chen RE, Monroy JM, Wedner HJ, Kulczycki A Jr, Mantia TL, O’Shaughnessy CC, Davis-Adams HG, Bertera HL, Adams LJ, Raju S, Zhao FR, Rigell CJ, Dy TB, Kau AL, Ren Z, Turner JS, O’Halloran JA, Presti RM, Fremont DH, Kendall PL, Ellebedy AH, Alter G, Diamond MS. mRNA vaccine boosting enhances antibody responses against SARS-CoV-2 Omicron variant in individuals with antibody deficiency syndromes. Cell Rep Med. 2022 Jun 21;3(6):100653. PMCID: PMC9179023
  1. Raju S, Tawiah KD, Farnsworth CW. A “total” interference. Clin Chem. 2022 Feb 1;68(2):372–373. PMID: 36103295
  1. Tonc E, Takeuchi Y, Chou C, Xia Y, Holmgren M, Fujii C, Raju S, Chang GS, Iwamoto M, Egawa T. Unexpected suppression of tumorigenesis by c-MYC via TFAP4-dependent restriction of stemness in B lymphocytes. Blood. 2021 Dec 16;138(24):2526–2538. PMCID: PMC8678995
  1. Raju S, Anderson NW, Robinson E, Squires C, Wallace MA, Zhang R, Burnham CAD, Parikh BA. Comparison of 6 SARS-CoV-2 molecular methods and correlation with the cycle threshold distribution in clinical specimens. J Appl Lab Med.; 2021 Nov 1;6(6):1452–1462. PMCID: PMC8436400
  1. VanBlargan LA, Adams LJ, Liu Z, Chen RE, Gilchuk P, Raju S, Smith BK, Zhao H, Case JB, Winkler ES, Whitener BM, Droit L, Aziati ID, Bricker TL, Joshi A, Shi PY, Creanga A, Pegu A, Handley SA, Wang D, Boon ACM, Crowe JE Jr, Whelan SPJ, Fremont DH, Diamond MS. A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope. Immunity. 2021 Oct 12;54(10):2399-2416.e6. PMCID: PMC8373659
  1. Hassan AO, Shrihari S, Gorman MJ, Ying B, Yuan D, Raju S, Chen RE, Dmitriev IP, Kashentseva E, Adams LJ, Mann C, Davis-Gardner ME, Suthar MS, Shi PY, Saphire EO, Fremont DH, Curiel DT, Alter G, Diamond MS. An intranasal vaccine durably protects against SARS-CoV-2 variants in mice. Cell Rep. 2021 Jul 27;36(4):109452. PMCID: PMC8270739
  1. Raju S*, Xia Y*, Daniel B, Yost KE, Bradshaw E, Tonc E, Verbaro DJ, Kometani K, Yokoyama WM, Kurosaki T, Satpathy AT, Egawa T. Identification of a T-bethi quiescent exhausted CD8 T cell subpopulation that can differentiate into TIM3+CX3CR1+ effectors and memory-like cells. J. Immunol. 2021. p. 2924–2936. PMCID: PMC8642473 *co-first authors
  1. Raju S, Verbaro DJ, Egawa T. PD-1 signaling promotes control of chronic viral infection by restricting type-I-interferon-mediated tissue damage. Cell Rep.; 2019 Nov 26;29(9):2556-2564.e3. PMCID: PMC6894421
  1. Raju S, Whalen DM, Mengistu M, Swanson C, Quinn JG, Taylor SS, Webster JD, Newton K, Shaw AS. Kinase domain dimerization drives RIPK3-dependent necroptosis. Sci Signal. 2018 Aug 21;11(544):eaar2188. PMCID: PMC6310155
  1. Milam AAV, Bartleson JM, Donermeyer DL, Horvath S, Durai V, Raju S, Yu H, Redmann V, Zinselmeyer B, White JM, Murphy KM, Allen PM. Tuning T cell signaling sensitivity alters the behavior of CD4+ T cells during an immune response. J Immunol. 2018 May 15;200(10):3429–3437. PMCID: PMC5940509
  1. Raju S, Kometani K, Kurosaki T, Shaw AS, Egawa T. The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection. PLoS Pathog. 2018 May;14(5):e1007053. PMCID: PMC5957453
  1. Brähler S, Zinselmeyer BH, Raju S, Nitschke M, Suleiman H, Saunders BT, Johnson MW, Böhner AMC, Viehmann SF, Theisen DJ, Kretzer NM, Briseño CG, Zaitsev K, Ornatsky O, Chang Q, Carrero JA, Kopp JB, Artyomov MN, Kurts C, Murphy KM, Miner JH, Shaw AS. Opposing roles of dendritic cell subsets in experimental GN. J Am Soc Nephrol. 2018 Jan 1;29(1):138–154. PMCID: PMC5748909
  1. Trembath AP, Sharma N, Raju S, Polić B, Markiewicz MA. A protective role for NKG2D-H60a interaction via homotypic T cell contact in nonobese diabetic autoimmune diabetes pathogenesis. ImmunoHorizons. 2017 Nov 1;1(9):198–212. PMCID: PMC5828234
  1. Raju S, Kretzmer LZ, Koues OI, Payton JE, Oltz EM, Cashen A, Polic B, Schreiber RD, Shaw AS, Markiewicz MA. NKG2D-NKG2D ligand interaction inhibits the outgrowth of naturally arising low-grade B cell lymphoma in vivo. J Immunol. 2016 Jun 1;196(11):4805–4813. PMCID: PMC4875802
  1. Le Borgne M*, Raju S*, Zinselmeyer BH, Le VT, Li J, Wang Y, Miller MJ, Shaw AS. Real-time analysis of calcium signals during the early phase of T cell activation using a genetically encoded calcium biosensor. J Immunol. 2016 Feb 15;196(4):1471–1479. PMCID: PMC4744592 *co-first authors
  1. Hass MR, Liow HH, Chen X, Sharma A, Inoue YU, Inoue T, Reeb A, Martens A, Fulbright M, Raju S, Stevens M, Boyle S, Park JS, Weirauch MT, Brent MR, Kopan R. SpDamID: Marking DNA bound by protein complexes identifies Notch-dimer responsive enhancers. Mol Cell. 2015 Aug 20;59(4):685–697. PMCID: PMC4553207

Opinions, Perspectives, and Reviews (Reverse Chronologic)

  1. Raju S, Adams LJ, Diamond MS. The many ways in which alphaviruses bind to cells. Trends in Immunology; 2023 Dec 22. PMID: 38135598
  1. Raju S, Shaw AS. New lamp posts allow for new views of the immunological synapse. Immunity. 2015. p. 781–783. PMID: 25992851
  1. Raju S, Shaw AS. What is the point of pseudokinases? eLife. 2015. p. e07771. PMCID: PMC4421857