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Multi-layered transcriptional control of glycogen metabolism coordinates thermogenic remodeling of white adipocytes in male mice. Haipeng Fu, Seoyeon Lee, Nathan R. Zemke, Weiwei Fan, Yunqing Wang, James Garza, David Tin, Bryce Villao, Bichen Zhang, Xianda Ma, Jinyang Zhang, Tangran Dong, Yuyao Ren, Michael Downes, Ronald M. Evans, Bing Ren & Alan R. Saltiel. Nature Communications (2025).
Neutrophils preserve energy storage in sympathetically activated adipocytes. Seunghwan Son, Cindy Xu, Janice Jang, Maddox Dinh, Yuliya Skorobogatko, Haipeng Fu, Joseph M Valentine, Garam An, Wei Ying, Ruth T Yu, Michael Downes, Ronald M Evans, Alan R Saltiel. Nature (2025). https://doi.org/10.1038/s41586-025-09839-6
Protocol for differentiating murine 3T3-L1 and SVF-derived preadipocytes and isolating crude mitochondrial fractions. Wisessaowapak C, Lee J, Kim H, Son S, Feng X, Chang L, Hoang A, Chen H, Bedsted S, Saltiel AR. STAR Protoc. 2025 Sep 19;6(3):104045. doi: 10.1016/j.xpro.2025.104045. Epub 2025 Aug 23. PMID: 40849911; PMCID: PMC12398810.
Hepatic glycogen directly regulates gluconeogenesis through an AMPK/CRTC2 axis in mice. Zhang B, Johnson MM, Yuan T, Nguyen TN, Okada J, Yang F, Xiaoli AM, Melikian LH, Xu S, Dadpey B, Pessin JE, Saltiel AR.J Clin Invest. 2025 Jun 2;135(11):e188363. doi: 10.1172/JCI188363. eCollection 2025 Jun 2.PMID: 40454488
Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation. Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne TE, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu RT, Downes M, Evans RM, Rydén M, Wabitsch M, Wang Z, Hakozaki H, Schöneberg J, Reilly SM, Huang J, Saltiel AR. Nat Metab. 2024 Feb;6(2):273-289. doi: 10.1038/s42255-024-00978-0. Epub 2024 Jan 29.
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. Cell Metab. 2023 Jun 6;35(6):1009-1021.e9. doi: 10.1016/j.cmet.2023.03.021. Epub 2023 Apr 20.
The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis. Zhao P, Sun X, Liao Z, Yu H, Li D, Shen Z, Glass CK, Witztum JL, Saltiel AR. JCI Insight. 2022 Sep 8;7(17):e155552. doi: 10.1172/jci.insight.155552.
Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome. Dantas Machado AC, Brown SD, Lingaraju A, Sivaganesh V, Martino C, Chaix A, Zhao P, Pinto AFM, Chang MW, Richter RA, Saghatelian A, Saltiel AR, Knight R, Panda S, Zarrinpar A. Cell Rep. 2022 Jul 5;40(1):111008. doi: 10.1016/j.celrep.2022.111008.
Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease. Huh JY, Saltiel AR. Exp Mol Med. 2021 Nov;53(11):1697-1705. doi: 10.1038/s12276-021-00712-w. Epub 2021 Nov 30.
β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. Valentine JM, Ahmadian M, Keinan O, Abu-Odeh M, Zhao P, Zhou X, Keller MP, Gao H, Yu RT, Liddle C, Downes M, Zhang J, Lusis AJ, Attie AD, Evans RM, Rydén M, Saltiel AR. J Clin Invest. 2022 Jan 18;132(2):e153357. doi: 10.1172/JCI153357.
p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes. Martins VF, LaBarge SA, Stanley A, Svensson K, Hung CW, Keinan O, Ciaraldi TP, Banoian D, Park JE, Ha C, Hetrick B, Meyer GA, Philp A, David LL, Henry RR, Aslan JE, Saltiel AR, McCurdy CE, Schenk S. JCI Insight. 2022 Jan 11;7(1):e141344. doi: 10.1172/jci.insight.141344.
Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes. Keinan O, Valentine JM, Xiao H, Mahata SK, Reilly SM, Abu-Odeh M, Deluca JH, Dadpey B, Cho L, Pan A, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Lusis AJ, Laakso M, Chouchani ET, Rydén M, Saltiel AR. Nature. 2021 Nov;599(7884):296-301. doi: 10.1038/s41586-021-04019-8. Epub 2021 Oct 27.
Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice. Yong J, Parekh VS, Reilly SM, Nayak J, Chen Z, Lebeaupin C, Jang I, Zhang J, Prakash TP, Sun H, Murray S, Guo S, Ayala JE, Satin LS, Saltiel AR, Kaufman RJ. Sci Transl Med. 2021 Jul 28;13(604):eaba9796. doi: 10.1126/scitranslmed.aba9796.
FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes. Abu-Odeh M, Zhang Y, Reilly SM, Ebadat N, Keinan O, Valentine JM, Hafezi-Bakhtiari M, Ashayer H, Mamoun L, Zhou X, Zhang J, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Kliewer SA, Mangelsdorf DJ, Saltiel AR. Cell Rep. 2021 Jun 29;35(13):109331. doi: 10.1016/j.celrep.2021.109331.
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ. Huang J, Linares JF, Duran A, Xia W, Saltiel AR, Müller TD, Diaz-Meco MT, Moscat J. Nat Commun. 2021 May 17;12(1):2876. doi: 10.1038/s41467-021-23085-0.